The goal of this function is to visualize the position of functional features within a gene, and indicate whether these features are presented in all transcripts (constitutive) or only in some transcripts (alternative).

To suit the needs of different studies, whether a feature is alternative will be investigated accoding to three independent standards in the selection of transcripts :

(1) All coding transcripts;

(2) Transcripts whose CDS are longer than a certain ratio of the longest CDS, the ratio can be modified in the next section;

Transcripts with short CDS have few predicted features, thus making features predicted in other transcripts alternative. By default the threshold is set to 0.25. This value will not interfere with the first or third standards.

(3) Transcripts whose CDS overlaps with the feature.

This standard is more useful for alternative splicing where an alternative region flancked by constititive regions.

Please consult the help page for a detailed explaination.

Please enter a gene :

Accept HGNC / MGI symbols (case insensitive) or Ensembl Gene ID (e.g. ENSG00000100320 in human or ENSMUSG00000033565 in mouse).

Please select the species : :

• Human GRCh38 (hg38)
• Mouse CRCm39 (mm39)

Please select one (recommended) or more prediction tool(s) from the following list. To start exploring, choose only Pfam. :

• Pfam: protein families and domains
• SFLD: protein families
• PANTHER: gene classification by functions
• Hamap: High-quality Automated and Manual Annotation of Microbial Proteomes
• ProSiteProfiles: protein domains, families, functional sites and associated patterns and profiles
• ProSitePatterns: protein domains, families, functional sites and associated patterns and profiles
• SMART: domain architectures
• CDD: protein domains and families
• PRINTS: protein fingerprints (groups of conserved motifs used to characterise protein families)
• TIGRFAM: protein families
• PIRSF: protein families and domains
• SUPERFAMILY: structural and functional annotations
• Gene3D: protein families and domain architectures
• Coils: coiled coil regions
• MobiDBLite: intrinsically disordered regions

Please note that each tool is designed to predict a different set of features of the protein sequence. A detailed description of the tools can be found at InterPro website. Choosing multiple tools may produce redundancy in the result if they are designed to predict similar features and also make the plot cumbersome.

(Optional) Change the CDS Length Ratio for the transcript selection:

Higher threshold retains fewer transcripts. Use the default value (0.25) to start exploring.

Please enter a decimal number between 0 and 1 (e.g. 0.25). Percentage is not accepted.

It usually takes about 20~30 seconds to load the result page.